Clinical Study of Lobular Capillary Hemangioma in Nasal Cavity / 대한이비인후과학회지

BACKGROUND AND OBJECTIVES: Lobular capillary hemangioma (pyogenic granuloma) is a benign rapidly growing hemorrhagic lesion of unknown etiology and vascular proliferation of endothelial cells arranged in a characteristic pattern of circumscribed capillaries arranged in lobules. The disease usually affects the skin and the oral mucosa, but nose is a relatively rare location. The clinical impression of some lesions can often be misleading due to easy bleeding mass. The purpose of this paper is to present a series of patients seen over a period of 10 years at Inje University Pusan Paik Hospital with nasal capillary hemangioma. MATERIALS AND METHOD: We assessed 19 patients who were confirmed as lobular capillary hemangioma histopathologically and treated at Inje University Pusan Paik Hospital from 1988 to 1998. RESULTS: The study group was composed of 19 patients including nine males and ten females. The ages ranged from 3 to 58 years, with a mean of 36.6 year and four of the ten female patients were pregnant. Epistaxis with nasal obstruction was the most marked symptom. Eight lesions arose from the nasal septum, 7 from the inferior turbinates, 8 from the lateral nasal wall and one from the nasal floor. The size of masses ranged within 1 cm in 11 of the 19 cases. All patients were treated by simple excision and electrocauterization, with only one showing recurrence. CONCLUSION: Uncommon lesions should also be considered in the differential diagnosis of a rapidly growing hemorrhagic lesion if they are within the nasal cavity. Clinical and histological diagnostic pitfalls occur frequently.

Analysis of the T Lymphocyte Subsets Using Flow Cytometry in Sudden Deafness / 대한이비인후과학회지

BACKGROUND AND OBJECTIVES: Although there are a number of reports concerned with the role of immunity in the sudden onset of progressive sensorineural hearing loss, there are only a few references dealing with the involvement of immuneme- mediated mechanism in sudden deafness. This study was performed to define the alteration of peripheral blood T lymphocyte subsets in a group of patients with sudden deafness. MATERIALS AND METHODS: The study was carried out prior to the start of and after the steroid therapy. Thirty two patients (18 men and 14 women : mean age, 43.19 years) were compared with 15 healthy control subjects (7 men and 8 women : mean age, 44 years). Patients were divided into 2 groups according to their responses to the steroid therapy. RESULTS: A decreased number of both CD4' helper cells (38.44% vs 42.36%; p < 0.05) was observed in the patient group compared with those in the control group. In the group of patients who showed good response to the steroid therapy, there was a tendency toward normalization of the CD4 (pretreatment, 34.41%; posttreatment, 43.91%) cell counts, with a slight decrease in the CD8' population (pretreatment, 20.66%: posttreatment, 19.16%). However, there was no significant increment in patients with the poorer response when there was a increase in the CD4' (pretreatment, 32.12% ; posttreatment, 38.6%) cell counts after the steroid therapy. CONCLUSION: These results demonstrate that there is significant abnormality in the subpopulations of lymphocytes in patients with sudden hearing loss, suggesting the immune system as a possible etiopathogenic factor in this entity.

A Case of Primary Myxoid Liposarcoma of the Neck / 대한이비인후과학회지

Liposarcoma is a relatively common malignant tumor that can be originated from adipose tissue in the body, especially in the lower extremity and in the retroperitoneal space. But it is extremely rare in the head and neck region. Liposarcoma can be classified histopathologically into four subtypes; well differentiated, myxoid, round cell, and pleomorphic type. The prognosis of liposarcoma is known to be generally poor due to the high local recurrence rate in spite of complete resection. We report a case of myxoid liposarcoma of the neck in a 41-year old male, who was treated with primary excision of tumor and postoperative radiation therapy. The histopathology, clinical appearance, management and prognosis of this rare condition are discussed.